When your dog suffers from persistent skin issues like infections, hot spots, flaking, or stubborn itchiness, a regular shampoo just won’t cut it. That’s where medicated dog shampoos come in — specially formulated to treat and soothe conditions like seborrhea, dermatitis, bacterial or fungal infections, and more. 🐶🩺
In this guide, we’ve curated the top-rated medicated shampoos for dogs that are safe, effective, and often vet-recommended. Whether your dog needs antifungal, antibacterial, or anti-inflammatory support, each option listed here is selected for its proven results, gentle formulas, and high demand. ✅💧 You can also keep your dog’s coat looking its best between baths with our guide to brushes, combs, rakes, and de-shedding tools. For extra shine and healthy skin from the inside out, explore our skin and coat supplements for dogs.
💡 A Note from HeartForPooches
We only feature products we truly recommend. If you choose to buy through our links, it won’t cost you anything extra — but it helps support our work so we can keep bringing you trusted, high-quality finds for your dog. Thank you for your support! 🐾
Note: Product packaging may vary by region, but the formula remains the same across trusted sellers.
Let’s dive into the best options trusted by pet parents and professionals alike — so your dog can get real relief, and you can have peace of mind. 🌿✨
🧴 1. Pet Honesty Chlorhexidine Shampoo – Antibacterial Cleansing and Odor Remover (16 fl oz)
Quick Pick: Veterinary-strength shampoo with chlorhexidine and ketoconazole to target bacteria, yeast, and fungal infections while soothing irritated skin with aloe vera.
Function: Treats skin conditions such as hot spots, rashes, wounds, infections, and yeast-related itch while neutralizing odors and calming irritation.
Key Features:
• Contains 2% chlorhexidine and 1% ketoconazole for antibacterial and antifungal effectiveness
• Infused with aloe vera to moisturize and soothe dry, itchy, or inflamed skin
• Helps eliminate odor caused by skin pathogens with a mild cucumber-melon scent
• Free from sulfates, parabens, and harsh chemicals; safe for dogs and cats
• Made in the USA in GMP-compliant facilities for quality and safety
Best For: Dogs or cats with bacterial or fungal skin infections, hot spots, yeast-related itching, or stubborn odors that don’t improve with regular shampoos.
Key Ingredients: Chlorhexidine gluconate (2%), ketoconazole (1%), aloe vera, cucumber-melon fragrance, purified water, gentle cleansing agents.
👉 Buy on 🔴 iHerb.com
👉 Buy on 🔴 Shopee.sg
👉 Buy on 🔴 Shopee.sg
👉 Buy on 🔴 iHerb.sg
🧴 2. TRM Pet Chaminol Medicated Shampoo (500 ml)
Quick Pick: A gentle yet potent medicated shampoo combining sulfur, salicylic acid, and para-chloro-meta-cresol—designed to cleanse deeply and treat bacterial and fungal skin issues while nourishing the coat.
Function: Delivers therapeutic relief for skin infections and coat build-up without stripping essential oils, promoting healthier skin and a shiny, manageable coat.
Key Features:
• pH-balanced formula tailored for both dogs and cats — maintains healthy skin and coat integrity
• Active ingredients: 2% sodium thiosulfate (sulfur source), 0.5% salicylic acid, 0.2% para-chloro-meta-cresol for infection control and descaling
• Provides deep cleansing with degreasing and descaling action to tackle flakes, impurities, and buildup
• Enriched with vitamin B12 and panthenol to help prevent split ends and support healthy hair growth
Best For: Pets battling chronic skin infections, excessive oiliness or scale, or needing medicated grooming that’s tough on microbes but kind to the coat
👉 Buy on 🔴 Shopee.sg
🧴 3. Douxo S3 PYO Medicated Shampoo – Vet-Recommended Antiseptic Relief for Bacterial & Yeast Infections
Quick Pick: A vet-formulated antiseptic and hydrating shampoo containing 3% chlorhexidine and 0.5% Ophytrium—ideal for treating bacterial or yeast skin infections while restoring skin barrier health.
Function: Gently cleanses and hydrates inflamed, compromised skin; effectively targets infection-causing microbes and supports skin balance.
Key Features:
• 3% chlorhexidine digluconate for powerful antibacterial and antifungal action
• 0.5% Ophytrium—a skin-supporting natural extract that soothes, balances, and strengthens skin integrity
• Free from soap, sulfates, parabens, phthalates, nanoparticles, and colorants
• Hypoallergenic fragrance and pH-adjusted formula (vet-tested)
Best For: Pets with bacterial or yeast-based skin infections that need both cleansing and restoration of skin comfort.
Key Ingredients: Chlorhexidine digluconate (3%), Ophytrium (0.5%), panthenol, pentavitin, gentle cleansing base, hypoallergenic fragrance.
👉 Buy on 🔴 Amazon.com
👉 Buy on 🔴 Amazon.sg
🧴 4. Animedx SeboFIX Medicated Shampoo
Quick Pick: A clinic-grade antifungal and antibacterial shampoo with lavender and lemongrass oils plus ceramides — perfect for providing rapid itch relief, repairing skin, and restoring a dull coat’s natural glow.
Function: Targets fungal and bacterial skin issues while deeply moisturizing and rejuvenating damaged, itchy skin.
Key Features:
• 2% chlorhexidine gluconate for broad-spectrum antibacterial action
• 2% miconazole nitrate for effective antifungal treatment
• Ceramide complex to repair and restore the skin barrier and coat texture
• Lavender and lemongrass essential oils to reduce odor and soothe irritation
• Made in the USA
Best For: Dogs or cats with dry, itchy, flaky, or infection-prone skin in need of targeted medicated care
Key Ingredients: Chlorhexidine gluconate, miconazole nitrate, ceramide complex, lavender oil, lemongrass oil, gentle cleansers
👉 Buy on 🔴 Shopee.sg
👉 Buy on 🔴 Shopee.sg
👉 Buy on 🔴 Shopee.sg
🧴 5. Nootie Medicated Pet Shampoo – Chlorhexidine Dog Shampoo for Itch Relief (Two Sizes)
Quick Pick: Targets skin infections and stubborn itch with a powerful 2% chlorhexidine formula – perfect for dogs with recurring irritation or hot spots.
Function: Antibacterial medicated shampoo for dogs with itchy skin, redness, hot spots, and mild skin infections. Helps eliminate bacteria that cause irritation.
Key Features:
• Contains 2% Chlorhexidine Gluconate – a powerful antibacterial agent
• Helps soothe itching, redness, and skin discomfort
• Deodorizes and leaves a clean, fresh scent
• Soap-free, pH balanced, and safe for regular use
• Suitable for dogs with sensitive or allergy-prone skin
Best For: Dogs suffering from bacterial skin infections, hot spots, or chronic itching.
Key Ingredients: Chlorhexidine Gluconate (2%)
👉 Buy on 🔴 Amazon.com
🧴 6. ZYMOX® Medicated Shampoo (12 oz / 355ml)
Function: Soothes irritated, inflamed, and allergy-prone skin with a gentle, enzyme-based formula.
Key Features:
• Contains the patented LP3 Enzyme System to combat bacteria, fungus, and yeast
• Free from harsh detergents, parabens, and chlorines
• Tear-free and non-drying – won’t strip natural oils
• Made in the USA and trusted by veterinarians
• Ideal for dogs with chronic skin issues, sensitivities, or itching
Best For: Dogs with sensitive, itchy, or infected skin; allergy-prone breeds; dogs with frequent hot spots or fungal infections
Key Ingredients: Lactoperoxidase, Lactoferrin, Lysozyme, vitamins A, B5 and E
👉 Buy on 🔴 Shopee.sg
👉 Buy on 🔴 Amazon.sg
🧴 7. CeraSoothe CHX Plus MC Antiseptic Shampoo (16 oz)
Function: A medicated veterinary shampoo that treats bacterial and fungal skin infections while nourishing and repairing the skin barrier.
Key Features:
• Contains 2% Chlorhexidine and 2% Miconazole for broad-spectrum antimicrobial action
• Fortified with ceramides and avenanthramides to soothe, hydrate, and strengthen the skin
• Helps manage conditions like ringworm, yeast infections, and seborrheic dermatitis
• Soap-free, gentle, and pH-balanced for regular use
• Suitable for both dogs and cats with sensitive or infection-prone skin
Best For: Dogs with chronic skin infections, allergies, or irritated skin needing vet-grade care
Key Ingredients: Chlorhexidine Gluconate (2%), Miconazole Nitrate (2%), Ceramide Complex, Oat-derived Avenanthramides
👉 Buy on 🔴 Amazon.com
🧴 8. Sulfodene Medicated Shampoo & Conditioner for Dogs (12 oz / 355 ml)
Function: A dual-action formula that relieves itching, flaking, and scaling while infusing extra conditioning for a clean, healthy coat.
Key Features:
• Contains sulfur (exfoliates and helps reduce scaling) and coal tar (anti‑inflammatory, antifungal) for targeted relief
• Enriched with aloe vera to soothe skin and leave the coat soft, shiny, and conditioned
• Deep-cleans, deodorizes, and keeps your pup looking and smelling great
• Gentle enough for regular use, ideal for routine grooming or to maintain skin comfort
Best For: Dogs with dry, itchy, flaky, or irritated skin; those in need of a deep-cleaning, soothing wash
Key Ingredients: Sulfur, Coal Tar Solution, Aloe Vera
👉 Buy on 🔴 Amazon.com
👉 Buy on 🔴 Shopee.sg
👉 Buy on 🔴 Amazon.sg
🧴 9. Arava Natural Medicated Dog Shampoo (13.5 oz / 400 ml)
Function: A botanical, therapeutic shampoo that combats bacterial, fungal, and yeast infections while promoting skin healing and coat health.
Key Features:
• Formulated with 28 active natural ingredients, including Dead Sea minerals and botanical oils
• Targets hot spots, abrasions, ringworm, and other skin irritations
• Antibacterial, antifungal, anti-yeast, and anti-itch properties
• Free from parabens, SLS, sulfates, and artificial dyes
• Light, pleasant scent and moisturizing for regular use
Best For: Dogs with recurring skin infections, hot spots, or allergic flare-ups; ideal for owners seeking a natural medicated solution
Key Ingredients: Dead Sea Minerals, Pomegranate, Reishi Mushroom, Rosemary, Aloe Vera, Tea Tree Oil, and Oatmeal Extract
👉 Buy on 🔴 Amazon.com
👉 Buy on 🔴 Amazon.sg
🧴 10. Absorbine Silver Honey Rapid Skin Relief Medicated Shampoo (16 oz / 473 ml)
Function: A powerful yet gentle medicated shampoo that treats bacterial and fungal skin issues while hydrating and repairing the skin barrier.
Key Features:
• Combines 0.05% MicroSilver BG™ and medical-grade Manuka honey for antimicrobial and healing action
• Soothes itchy, inflamed, or infected skin while supporting healthy microbiome balance
• Ideal for treating hot spots, rashes, skin infections, and post-surgical washing
• Free from parabens, sulfates, fragrances, alcohol, steroids, and antibiotics
• Light-lather, pH-balanced formula safe for routine use
Best For: Dogs with stubborn skin issues, surgical recovery, or owners looking for a vet-inspired natural treatment
Key Ingredients: MicroSilver BG™, Manuka Honey, Plant-Based Surfactants
👉 Buy on 🔴 Amazon.com
🧴 11. Curaseb Chlorhexidine 4% Medicated Shampoo (8 oz / 236 ml)
Function: A veterinary-strength medicated shampoo that treats bacterial, fungal, and yeast infections while relieving skin inflammation and odor.
Key Features:
• Contains 4% chlorhexidine gluconate for powerful antimicrobial action
• Targets skin infections, hot spots, ringworm, acne, and paw-licking irritation
• Deodorizes and cleans without stripping essential oils
• Paraben-free and safe for routine use with a mild blueberry scent
• Made in the USA and tested for purity and effectiveness
Best For: Dogs with persistent skin infections, allergy flare-ups, or odor-related issues needing clinical-level care
Key Ingredients: Chlorhexidine Gluconate (4%), Mild Surfactants, Fragrance
👉 Buy on 🔴 Amazon.com
🧴12. GNC Pets Ultra Medicated Hypo-Allergenic Dog Shampoo (Fragrance-Free)
Quick Pick: A gentle, fragrance-free medicated shampoo formulated to soothe itchy, allergy-prone skin using anti-irritant ingredients and hydrocortisone.
Function: Delivers calming relief for dogs with sensitive or inflamed skin by providing deep yet gentle cleansing while reducing itch and irritation.
Key Features:
• Free from added fragrances or dyes to minimize allergic reactions
• Medicated formula contains hydrocortisone and diphenhydramine to relieve itching and soothe skin discomfort
• Hypoallergenic base, ideal for dogs with chronic or seasonal allergies
Best For: Dogs suffering from dry, itchy, or inflamed skin who need a mild, therapeutic wash without harsh chemicals or strong scents.
👉 Buy on 🔴 Amazon.sg
🧴13. Vet’s Best Oatmeal Medicated Dog Shampoo (16 oz)
Quick Pick: A veterinarian-formulated, oatmeal-based shampoo enhanced with salicylic acid, tea tree oil, and vitamin B5 to gently cleanse and soothe dry, flaky, and itchy skin.
Function: Delivers deep yet mild cleansing while restoring skin health—reducing dandruff and irritation and promoting a healthy glow.
Key Features:
• Combines salicylic acid with natural soothing agents such as colloidal oatmeal, tea tree oil, and vitamin B5
• Helps eliminate dandruff and flaking, while cleansing and stimulating skin for improved circulation and health
• Tightens pores, moisturizes itchy skin, and calms irritation for a renewed coat
• Veterinarian formulated for reliable performance and gentle care—won’t interfere with topical flea and tick treatments
Best For: Dogs suffering from dry, flaky, or irritated skin—perfect for regular baths that cleanse, soothe, and support lasting coat and skin health.
👉 Buy on 🔴 Amazon.com
👉 Buy on 🔴 Amazon.sg
💡 Bonus Tips
• Always leave the shampoo on your dog’s skin for 5–10 minutes before rinsing to let the chlorhexidine work effectively.
• Use lukewarm water during rinsing — hot water can further irritate sensitive skin.
• For dogs with recurring infections or chronic conditions, consider pairing with a medicated spray or mousse from the same brand between washes.
• Store the bottle in a cool, dry place to preserve potency — chlorhexidine can degrade with heat exposure.
• Avoid use around the eyes or inside the ears — use a damp cloth to clean the face instead.
❓ Frequently Asked Questions
Q: Is this shampoo safe for regular use?
A: Yes, but only as directed. While safe for most dogs, it’s best used 1–2 times per week or as recommended by your vet.
Q: Can I use this on puppies?
A: It’s generally formulated for adult dogs. Check with your vet before using on puppies under 12 weeks old.
Q: What should I do if my dog licks the shampoo?
A: Rinse thoroughly after application and monitor for signs of irritation. While not toxic in small amounts, ingestion should be avoided.
Q: Is the “Extra Strength” version different from the Amazon one?
A: Both contain 4% chlorhexidine and come in 8 oz bottles. The label differences are due to regional marketing and packaging updates, not formula changes.
📝 Final Thoughts
Medicated shampoos are a valuable tool for managing common skin issues in dogs, from itching and allergies to infections and hot spots. With the right active ingredients and a gentle base, they offer relief while supporting overall skin health. Always follow usage directions carefully, and consult your vet if your dog has a recurring or severe skin condition. A consistent grooming routine using a trusted medicated shampoo can make all the difference in keeping your dog’s skin calm, clean, and comfortable.