Whether it’s fireworks, vet visits, car rides, or separation anxiety, stress affects dogs more than many pet parents realize. Some dogs tremble, bark excessively, hide, or even refuse food — all common signs of canine anxiety and emotional stress.
That’s where calming supplements for dogs can help. These vet-formulated calming chews, oils, and soft bites are made with gentle, natural ingredients like chamomile, L-theanine, melatonin, and hemp to support relaxation without sedation. They help dogs feel calmer, more secure, and better able to cope with everyday triggers. Help your dog stay happy and stress-free with engaging dog toys to keep them occupied, and maintain their oral health with our dental treats.
We’ve handpicked some of the best calming supplements for dogs, trusted by thousands of dog owners for both daily anxiety relief and occasional use. Whether your dog is a nervous traveler, storm-phobic, or an anxious rescue, there’s a safe and effective option here to bring peace back into their day.
💡 A Note from HeartForPooches
Many of the products you’ll find here are premium-quality selections. When an item isn’t marketed as “premium,” it has been included only if the ingredients, materials, or design are safe, reliable, and effective. Every product featured has been handpicked to balance quality, functionality, and value — so you can feel confident in your choice. If you choose to buy through our links, it won’t cost you anything extra — but it helps support our work so we can keep bringing you trusted, carefully selected finds for your dog. Thank you for your support!🐾
📦 Notes: Product sizes and packaging may vary slightly between shopping sites. Always double-check before purchasing.
🌙 1. Zesty Paws Puppy Calming Bites – Turkey Flavor, 90 Soft Chews (157 g)
Quick Pick: Gentle, turkey-flavored calming chews with chamomile, L-theanine, and melatonin — perfect for easing puppy nerves without sedation.
Function: Specially designed for puppies, these soft chews promote relaxation during stressful events like crate training, vet visits, or travel. The formula features calming botanicals and amino acids that support a balanced mood and restful sleep, while being gentle on developing bodies.
Key Features:
• Contains organic chamomile and valerian root for natural calming support
• L-theanine and L-tryptophan promote serotonin production to reduce anxiety
• Includes melatonin for healthy sleep cycles without drowsy side effects
• Puppy-safe formula with no artificial flavors or synthetic preservatives
• Soft texture that’s easy for young dogs to chew and digest
Best For: Puppies experiencing separation anxiety or nervousness, calming during thunderstorms, car rides, or first grooming sessions, encouraging restful sleep at night, daily support for high-energy or easily overstimulated puppies
Key Ingredients: Organic chamomile, valerian root, L-theanine, L-tryptophan, melatonin
👉 Buy on 🔴 iHerb.com
👉 Buy on 🔴 iHerb.sg
🌙 2. Purina Pro Plan Veterinary Supplements FortiFlora Calming Care – 30 Sachets
Quick Pick: Clinically studied probiotic supplement that helps manage anxiety in dogs by supporting a healthy gut–brain connection.
Function: Developed by Purina’s veterinary science team, Calming Care contains a unique probiotic strain (BL999) shown to promote calm behavior in dogs experiencing stress, separation anxiety, or environmental changes. It works by supporting the gut microbiome — an essential player in regulating mood and emotional stability.
Key Features:
• Contains Bifidobacterium longum BL999, a probiotic clinically shown to help dogs remain calm
• Helps manage common anxiety triggers like separation, visitors, or changes in routine
• Easy-to-use powder sachets — mix into wet or dry food daily
• Recommended for daily use for best long-term results
• Backed by veterinary research and suitable for both dogs and cats
Best For: Dogs with general anxiety or stress-related behaviors, dogs adjusting to new environments or routines, long-term calming support through gut health, pet owners looking for a vet-trusted, non-sedating solution
Key Ingredients: Bifidobacterium longum BL999 (probiotic blend), liver flavor, maltodextrin
👉 Buy on 🔴 Amazon.com
👉 Buy on 🔴 Shopee.sg
🌙 3. VetriScience Calm & Confident Chews – Soft Chews (Veterinarian-Formulated) (Various Flavors and Sizes Available)
Quick Pick: Non-drowsy calming chews made with clinically studied Colostrum Calming Complex and L-theanine to support relaxed behavior during stressful events.
Function: VetriScience Calm & Confident is designed to help dogs maintain emotional balance in high-stress situations such as thunderstorms, vet visits, car rides, or being left alone. It works by supporting the nervous system with natural amino acids and bioactive proteins that promote calm without sedation.
Key Features:
• Contains Colostrum Calming Complex® Biopeptide Blend clinically shown to support relaxation
• Includes L-theanine (Suntheanine®) to help balance mood and reduce anxiety
• Non-drowsy formula helps maintain alertness and calmness together
• Duck-flavored soft chews that are easy to give and well accepted by dogs
• Suitable for daily use or occasional stressful events
Best For: Dogs with noise phobia (e.g., thunderstorms, fireworks), separation anxiety or travel-related stress, visits to the vet or groomer, dogs who become overstimulated in busy environments
Key Ingredients: Colostrum Calming Complex® Biopeptide Blend, L-theanine (Suntheanine®), thiamine (vitamin B1)
👉 Buy on 🔴 Amazon.com
👉 Buy on 🔴 Amazon.sg
🌙 4. Fera Pets Calming Support Powder – 60 Servings
Quick Pick: Clean-label calming powder made with organic botanicals and amino acids to support relaxation, emotional balance, and healthy sleep in both dogs and cats.
Function: This vet-developed calming powder blends organic herbs with key amino acids to help soothe nervousness, reduce restlessness, and promote calm behavior without sedation. Ideal for multi-pet households, it supports a balanced mood during stressful events like travel, thunderstorms, or separation.
Key Features:
• Made with organic hemp seed, valerian root, L-theanine, and GABA for natural calming
• Includes organic chamomile, passion flower, and ginger for gentle stress relief
• Clean, vegan formula — no fillers, soy, corn, gluten, or artificial preservatives
• Versatile powder format — easy to mix into wet or dry food
• Suitable for both dogs and cats; 60 servings per container
Best For: Dogs or cats with general anxiety or hyperactivity, multi-pet homes needing a shared calming solution, pets sensitive to chews or pills, daily mood support and occasional stress triggers
Key Ingredients: Organic hemp seed, L-theanine, valerian root, GABA, organic chamomile, passion flower, ginger root
👉 Buy on 🔴 Shopee.sg
👉 Buy on 🔴 Amazon.sg
🌙 5. Life Extension DOG Stress & Behavior – Bacon‑Flavor 120 Soft Chews (~480 g)
Quick Pick: From the science-first team at Life Extension—this high-quality, veterinarian-formulated chew combines L‑theanine and melatonin for clean, proven calming support.
Function: Designed to promote calm behavior and support a healthy stress response in dogs during thunderstorms, travel, separation, or changes in routine. The formula uses melatonin (1 mg) and L‑theanine (50 mg per chew) to help your dog relax and stay content without sedation. It’s made in the USA using rigorous quality control.
Key Features:
• Premium formulation with L‑theanine and melatonin clinically shown to ease stress
• Delicious bacon‑flavored soft chews that are dog-friendly and easy to serve
• No artificial flavors or colors; non-GMO, gluten‑free formula
• Vet-backed supplement from a trusted brand known for research and purity
Best For: Dogs showing anxiety before bedtime or during stressful events, managing reactivity to fireworks, thunderstorms, or being left alone, owners who prefer a science-grade, non-prescription calming solution
Key Ingredients: L‑theanine (50 mg), melatonin (1 mg), bacon flavor, chickpea flour, canola oil, pork liver, glycerin, tapioca flour, sunflower lecithin, guar gum, tocopherols, sorbic acid
👉 Buy on 🔴 iHerb.com
👉 Buy on 🔴 iHerb.sg
🌙 6. VetriScience® Composure™ Long Lasting Calming Supplement for Dogs (50 Chews)
Quick Pick: Long-lasting calming chews with clinically proven ingredients that soothe stress for up to 8 hours — ideal for anxious or overactive dogs.
Function: Advanced calming support for dogs facing ongoing anxiety, environmental stress, or overexcitement.
Key Features:
• Clinically proven to begin working in as little as 30 minutes
• Effects last up to 8 hours per chew
• Includes patented colostrum complex and Shoden® Ashwagandha
• Ideal for dogs with separation anxiety, noise reactivity, or vet/travel stress
• Recommended by veterinarians and made in the USA
Best For: Dogs with moderate to severe anxiety, dogs left alone during the day, multi-dog homes, rescue dogs adjusting to new environments
Key Ingredients: Colostrum Calming Complex®, L-theanine (Suntheanine®), Thiamine (Vitamin B1), Shoden® Ashwagandha
👉 Buy on 🔴 Shopee.sg
🌙 7. Zesty Paws Ancient Elements Calming Bites – Bison Flavor, 90 Soft Chews
Quick Pick: Calming chews with a unique ancient grain base and clinically studied active ingredients for gentle, all-ages support.
Function: Designed to help dogs stay calm during daily stressors—separation, noise sensitivity, travel, storms—using a blend that supports composure and reduced tension.
Key Features:
• Ancient grain blend (quinoa, millet, amaranth, sorghum) provides natural nutrition and digestibility
• Suntheanine® (clinically studied L‑theanine) promotes relaxation
• Sensoril® Ashwagandha supports stress-adjustment and calm mood
• Includes hemp seed powder (source of stearidonic acid), valerian root, melatonin for holistic calm
• No artificial flavors, colors, or preservatives; NASC-quality certified; made in the USA
Best For: Dogs needing daily composure and emotional balance, all ages, including senior dogs with sensitivities to rich ingredients, owners focusing on whole‑food, clean‑label ingredients with proven calming actives
Key Ingredients: Quinoa, millet, amaranth, sorghum, Hemp Seed Powder, Suntheanine® (L‑theanine), Sensoril® (Ashwagandha), Valerian Root, Melatonin, Passionflower, Lemon Balm, Ginger Root
👉 Buy on 🔴 iHerb.com
🌙 8. Australian Pet Organics Calm Support – Certified Organic Powder (Options for Various Concerns)
Quick Pick: Organic Mood Support Powder with Brain-Boosting Botanicals
Function: Supports natural mood balance and emotional calm in dogs of all ages. Combines mood-leveling herbs and brain-nourishing foods to help manage anxiety with everyday use.
Key Features:
• Certified organic ingredients like Sprouted Rice Protein, St John’s Wort, Broccoli Powder, Almond Meal, and Green-Lipped Mussel Powder
• Supaw™ formula provides natural choline from sunflower lecithin for cognitive support
• Rich in antioxidants (Vitamin E & C), magnesium, tryptophan, and MCTs from coconut flour
• Free from artificial preservatives, additives, soy, wheat, or fillers • Made in Australia; suitable for puppies, adults, and seniors
• Scoop powder easily mixed into daily food — gentle for sensitive stomachs
Best For: Dogs with mild anxiety, nervousness, or stress reactivity, daily emotional support and cognitive wellness in multi-dog households, owners preferring certified-organic, whole-food botanical blends, puppies and seniors who need gentle nutrition-backed mood support
Key Ingredients: Sprouted Rice Protein, Coconut Flour, St John’s Wort Powder, Sunflower Lecithin Powder, Almond Meal, Oat Flour, Broccoli Powder, Apple Powder, Beef Bone Broth Powder, Green Lipped Mussel Powder
👉 Buy on 🔴 Shopee.sg
👉 Buy on 🔴 Shopee.sg
👉 Buy on 🔴 Shopee.sg
🌙 9. POPPAW Calming Chews for Dogs with Ashwagandha
Quick Pick: A calming daily chew featuring ashwagandha, chamomile, and L-theanine to help dogs manage anxiety and stress without drowsiness.
Function: Supports emotional balance and relaxation in dogs prone to stress, anxiety, or hyperactivity.
Key Features:
• Contains calming botanicals like ashwagandha, chamomile, and valerian root
• Includes L-theanine and L-tryptophan for mood and serotonin support
• Magnesium citrate helps soothe nervous tension
• Soft-chew texture makes it easy to feed daily
• Suitable for general anxiety, travel stress, storms, or hyperactivity
• Made in the USA with no artificial preservatives
Best For: Dogs with general anxiety, reactivity to loud noises, or separation stress. Also helpful for easing dogs into new environments or routines.
Key Ingredients: Ashwagandha, Chamomile, Valerian Root, L-Theanine, L-Tryptophan, Magnesium Citrate
👉 Buy on 🔴 Amazon.com
🌙 10. ThunderWunders Calming Chews for Dogs (120-Count)
Quick Pick: Trusted fast-acting calming chews with melatonin and L-tryptophan to help soothe dogs during fireworks, travel, vet visits, and separation stress.
Function: Supports calm behavior in stressful situations such as thunderstorms, grooming, car rides, vet visits, and being left alone. Ideal for dogs with situational anxiety.
Key Features:
• Contains melatonin, L-tryptophan, passionflower, thiamine (vitamin B1), chamomile, and ginger
• Starts working in approximately 30 minutes
• NASC certified and made in the USA
• Soft chew format with dog-friendly taste
• Suitable for all breeds and sizes with dosage by weight
• Non-drowsy formula with no known harsh side effects
Best For: Dogs prone to stress or anxious behavior during loud events, travel, grooming, or separation.
Key Ingredients: L-tryptophan, Melatonin, Thiamine Mononitrate, Passion Flower, Chamomile, Ginger
👉 Buy on 🔴Amazon.sg
🌙11. Kradle Calming Chews Bundle (Chicken + Peanut Butter & Bacon)
Quick Pick: Premium calming chew combo featuring two top flavors and a powerful botanical blend for daily anxiety relief.
Function: Helps reduce anxiety, overexcitement, and stress in dogs using a natural, non-sedating formula. Ideal for daily use or specific stress events like thunderstorms, fireworks, travel, or being left alone.
Key Features:
• Proprietary BotaniTek™ blend with Ashwagandha, L-Tryptophan, Chamomile, GABA, L-Theanine, Passionflower, and more
• Soft chews with dog-favorite taste — easy to administer
• NASC-certified for safety and transparency
• Made in the USA with globally sourced ingredients
• Great for dogs with separation anxiety, noise phobia, or routine stress triggers
Best For: Dogs experiencing chronic or situational stress, owners looking for a vet-trusted, natural calming aid with proven ingredients and flavor variety.
Key Ingredients: Ashwagandha, Chamomile, L-Tryptophan, L-Theanine, GABA, Passionflower, Magnolia Bark, Ginger Root
👉 Buy on 🔴 Amazon.com
👉 Buy on 🔴 Amazon.sg
🌙 12. Natural Rapport Calming Soft Chews for Dogs
Quick Pick: A soothing, cold-pressed chew with essential fatty acids, chamomile, passion flower, and valerian root—ideal for anxious pups and owners who want natural, gentle relief in a tasty format.
Function: Helps alleviate stress and support overall well-being with calming herbs and omega-rich oils, designed for continued, daily use.
Key Features:
• Proprietary cold-pressed process without heat or water to preserve potency and flavor
• Blend of organic hemp seed oil, hemp protein, chamomile, passion flower, valerian root, and L‑tryptophan for effective calming support
• Includes natural extras like ginger root, oat flour, flaxseed, coconut glycerin, rice flour, natural duck flavor, and antioxidant-rich tocopherols
Best For: Dogs prone to anxiety from noise, separation, travel, or routine stress—especially those whose owners prefer clean-label, whole-ingredient calming solutions
Key Ingredients: Organic hemp seed oil, organic hemp protein powder, organic chamomile powder, organic passion flower, valerian root, L-tryptophan, organic ginger root powder, flaxseed, and natural duck flavor
👉 Buy on 🔴Amazon.com
🌙 13. GNC Pet Wellness Advanced Calming Soft Chews for Dogs
Quick Pick: Chicken-flavored soft chews with thiamine, L-tryptophan, and colostrum—formulated to help dogs relax and stay calm without drowsiness.
Function: Supports relaxation and emotional balance in dogs during stressful situations, using a blend of calming nutrients and natural ingredients.
Key Features:
• 90 chicken-flavored soft chews per container, suitable for adult dogs of all breeds
• Contains thiamine (Vitamin B1) to support nervous system health
• L-tryptophan promotes serotonin production for calm mood support
• Colostrum provides immune-supportive benefits alongside relaxation aid
• Made in the USA for quality assurance and safety
Best For: Dogs experiencing anxiety from loud noises, travel, separation, or changes in routine—ideal for owners seeking a non-sedating, easy-to-administer calming solution
Key Ingredients: Thiamine (Vitamin B1), L-tryptophan, colostrum, vegetable glycerin, brewers dried yeast, flaxseed oil, rosemary extract, and natural chicken flavor
👉 Buy on 🔴 Amazon.sg
🌙 14. Pet Honesty Hemp Calming Max Strength Soft Chews – Duck
Quick Pick: A higher-dose, vet- and nutritionist-formulated calming chew that leverages a potent blend of natural ingredients—Valerian root, Chamomile, Gingko Biloba, L-Theanine, Ashwagandha, Passion Flower, Melatonin, and more—to provide serious relief during stress or anxiety.
Function: Offers robust calming support for dogs during high-stress situations like thunderstorms, fireworks, or separation—without sedation.
Key Features:
• Contains the Pure Vitality Blend™ in a max-strength formula, backed by vet and nutritionist approval; carries the NASC Quality Seal
• Made in the USA with clean, thoughtful ingredients and transparent manufacturing standards
Best For: Dog owners needing a stronger, veterinary-quality supplement for dogs that experience moderate to severe anxiety—but still prefer a non-prescription, chewable solution.
👉 Buy on 🔴 iHerb.com
👉 Buy on 🔴 iHerb.sg
📝 Bonus Tips
For better results, give calming supplements 30 to 60 minutes before a known stress trigger, like a vet visit or thunderstorm. Pair it with a quiet space, soothing music, or a favorite toy to help your dog feel even more secure.
❓ Frequently Asked Questions
Q: Can I give calming supplements every day?
A: Many are designed for daily use, but always check the label. Some are better suited for occasional support during stressful events.
Q: Are calming supplements safe for all dogs?
A: Most premium calming chews use natural ingredients like L-theanine and chamomile, but it’s still best to consult your vet — especially if your dog is on medication or has a health condition.
Q: Will these make my dog drowsy?
A: Not typically. High-quality calming supplements aim to ease anxiety without full sedation, so your dog stays relaxed but alert.
🐶 Final Thoughts
While options are still limited in the premium calming supplement space, the products listed here are among the best available. They’re backed by reputable brands, clean ingredients, and solid customer trust. If your dog struggles with stress, these calming aids might just make everyone’s day a little more peaceful.